Notably, the expression levels of some chemokine genes were consistently decreased after inhibition of CacyBP and Myd88 (Fig. 4D), and we verified these alterations by qRT-PCR and confirmed that, compared to the control group, the mRNA expression levels of CX3CL1, CCL14 and CCL15 were significantly reduced after silencing CacyBP and Myd88 in HCC cells (Fig. 4E-4 and S3B-S3F). The gene discussed is CACYBP; the disease is hepatocellular carcinoma.