We identified 34 cellular senescence-associated core genes from previously published literature [28], excluding undetected genes (GUCY1B1), pseudogenes (WTAPP1),and noncoding RNAs (C1ORF147),leaving 31 cellular senescence-associated core genes for further analysis.Most of the cellular senescence-related genes (SRGs) (30/31, 96.78%) were differentially expressed between tumour tissues and adjacent nontumor tissues (Fig. 1A). The gene discussed is GUCY1B1; the disease is neoplasm.