Additionally, previous research has suggested that AP000696.2, LINC00645, and PTCSC3 have potential as biomarkers for different cancers.Additionally, previous research has suggested that AP000696.2, LINC00645, and PTCSC3 have potential as biomarkers for different cancers.AP000696.2 exhibits superior predictive performance compared to traditional tumor markers in esophageal squamous cell carcinoma and may affect patient prognosis and treatment by regulating angiogenesis [66, 67]. The gene discussed is LINC00645; the disease is esophageal squamous cell carcinoma.