For example, the interaction between lncRNA SNHG14 and miR-5590-3p upregulates Zinc finger E-box-binding homeobox 1 (ZEB1) to activate the PD-1/PD-L1 immune checkpoint, leading to the inactivation of CD8 + T cells and promoting immune escape of tumor cells in diffuse large B-cell lymphoma [93]. The gene discussed is CD274; the disease is neoplasm.