The expression levels of hub genes were significantly correlated with the expression levels of multiple glaucoma-related genes, among which HSPA8 was significantly negatively correlated with CYP1B1 (Pearson r = − 0.48) and RPL15 was significantly positively correlated with WDR36 (Pearson r = 0.58) (Fig. 8B). This evidence concerns the gene HSPA8 and glaucoma.