RPL15 knockdown inhibited p53 degradation through ribosomal stress, and increased stability and transcriptional activity of p53 to mediate cell cycle arrest and apoptotic cell death, which might be the mechanism, by which RPL15 knockdown promoted the apoptosis of hepatocellular carcinoma, colon cancer and leukemia cells through the intrinsic pathway of mitochondria [61, 64, 71]. The gene discussed is TP53; the disease is leukemia.