After adjusting for other potentially confounding factors, including smoking status, drinking, physical activity, BMI, albumin, serum iron, cholesterol, phosphorus, total protein, uric acid, serum vitamin D, sodium, potassium, hemoglobin, calcium intake, diabetes, arthritis, kidney failure, osteoporosis, thyroid disease, depression, the negative association remained significant (all P < 0.001). This evidence concerns the gene ALB and depressive symptom measurement.