For example, necroptosis-related genes including TPM2, PPP1R3G, IGF2BP1, ID1, HNRNPF, and CCT6A as well as immunologic cell death-related genes including PSCA, NT5E, H2AX, FGF2, BIRC3 were significantly expressed in high-risk groups indicating these genes play potentially critical roles in cancer development and progression. The gene discussed is H2AX; the disease is cancer.