In our study, we constructed a signature consisting of 14 CDI-related genes which was a promising predictor of LUAD prognosis including HNRNPF, PPP1R3G, IGF2BP1, TLR2, NT5E, BIRC3, PSCA, FGF2, MS4A1, CCT6A, ID1, TPM2, MYO6, H2AX. Here, H2AX is linked to clostridium difficile infection.