RBPJ was increased in CD8+ T cells from human tumour tissues39, and co-expressed with HAVCR2 in intratumoral CD8+ T cells from patients with non-small cell lung cancer (NSCLC)40 and in patients with colorectal cancer (CRC)41 (Fig. 5a and Extended Data Fig. 8a). This evidence concerns the gene CD8A and non-small cell lung carcinoma.