In turn, TAM recruit or activate endothelial cells to produce vascular endothelial growth factor A (VEGF-A), epidermal growth factor (EGF), C-X-C motif chemokine ligand 8 (CXCL8), and CXCL12 to promote tumor angiogenesis and continuously provide nutritional support for malignant cells [29, 30]. Here, EGF is linked to neoplasm.