We then performed Gene Set Enrichment Analysis (GSEA) [25] on the DEGs for both H2009 and H441 cell lines and found significant associations between STK11 loss and altered tumor-intrinsic cytokine signaling, specifically upregulation of genes within the Gene Ontology (GO) term “Cytokine Activity” (GO: 0005125) (Fig. 1D). Here, STK11 is linked to neoplasm.