In the present study, we prepared a selected β2AR agonist, Formoterol (FMT) as Solid Lipid Nanoparticles (SLNs) surface modified with polysorbate-80 (PS80) (FMT-SLNs-PS80) and evaluated its brain specific delivery and anti-Parkinson’s efficacy. Here, ADRB2 is linked to Parkinsonism.