Since, BG enhances the deposition of collagen, the over-expression of CD31, down-regulates MCP-1 and HSP-70 expression, restores Cx43 and Panx3 expression's levels without causing any negative side effects, suggesting that it would be a novel way to deal with the serious repercussions of diabetes (impaired wound healing). This evidence concerns the gene GJA1 and diabetes mellitus.