To functionally validate the effect of MAIT cells in renal inflammation, we performed gain- and loss-of-function experiments, comparing the histopathological and clinical outcomes of B6 (low MAIT cell frequency), B6-MAITCAST (4-fold increase in MAIT cell frequency, see Fig. 2a, b), and Mr1−/− (MAIT cell deficiency) mice in experimental cGN. This evidence concerns the gene MR1 and childhood gender nonconformity.