We thus examined the amounts of phospho-CaMKII (Thr-286) (Fig. 6E) and oxidized methionine-281/282 CaMKII (ox-CaMKII) (Fig. 6F) in the heart in the four groups and found that they were significantly increased in the BO (phospho-CaMKII [Thr-286]: Control vs. BO; 100 ± 38 vs. 195 ± 28%, P < 0.01 vs. Control; ox-CaMKII: Control vs. BO; 100 ± 29 vs. 155 ± 26%, P < 0.01 vs. Control). The gene discussed is CAMK2G; the disease is bronchiolitis obliterans syndrome.