RYR2 and bronchiolitis obliterans syndrome: Phospho-ryanodine receptor 2 (RyR2) (Ser-2814) was significantly increased in the heart of BO mice (Control vs. BO; 100 ± 16 vs. 164 ± 20%, P < 0.01 vs. Control) (Fig. 7C), and this increase was significantly attenuated by Cap (BO vs. BO + Cap; 164 ± 20 vs. 88 ± 27%, P < 0.01 vs. BO) (Fig. 7C).