Expression of α-SMA was significantly increased in cardiac muscle of BO mice (Control vs. BO: 100 ± 31 vs. 238 ± 85%, P < 0.05 by one-way ANOVA followed by the Tukey–Kramer post hoc test), and the increase was significantly suppressed by Cap (BO vs. BO + Cap: 238 ± 85 vs. 112 ± 52%, P < 0.05 by one-way ANOVA followed by the Tukey–Kramer post hoc test) (Fig. 3C). This evidence concerns the gene ACTA1 and bronchiolitis obliterans syndrome.