Upregulation of genes mediating increased cytotoxicity and function during malaria was balanced by increases in multiple negative regulators of NK cells, including TNFRSF4 (encoding CD134/OX4068), TNFRSF9 (encoding CD137/4-1BB69), TNFRSF18 (encoding CD357/GITR70), LAG371, HAVCR2 (encoding TIM-372) and CBLB73. The gene discussed is TNFRSF4; the disease is malaria.