Along with increased inflammatory and cytotoxic capacity, there was a suggestion of increased antigen presenting properties during infection, with upregulation of HLA-II related genes (CD74, HLA-DPB1, HLA-DQB1), and genes related to endocytosis and intracellular vesicle trafficking (such as SNX9 and SYNJ2). The gene discussed is HLA-DQB1; the disease is infection.