Accumulating evidence has demonstrated that proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, and monocyte chemoattractant protein 1 (MCP-1), play critical roles in the occurrence and development of ALF, which together lead to hepatocyte death and liver failure [3]. The gene discussed is CCL2; the disease is Hepatic failure.