MSS CRC IFNG+CD8+ T cells with exclusive TCRs had an extremely low number of cells positive for ENTPD1 as well as a very small number of both PDCD1+HAVCR2 ‘pre-exhausted’ and PDCD1+HAVCR2+ ‘exhausted’ profiles, compared to MSI CRC (Supplementary Fig. S5e). This evidence concerns the gene CD8A and colorectal carcinoma.