Herein, single cell transcriptomes of 28,773 CD8+ T cells from 60 patients (11,420 CD8+ T cells from 22 MSI CRC patients and 17,353 CD8+ T cells from 41 MSS CRC patients) across five cohorts from Korea, Belgium, and Singapore, were integrated to create one of the largest CD8+ T cell single cell datasets with balanced coverage for MSI/MSS CRC (Fig. 1a). The gene discussed is CD8A; the disease is colorectal carcinoma.