CD8A and colorectal carcinoma: When comparing the CD8+ T cell subpopulation phenotypes between MSI and MSS CRC, the top 5 most enriched subpopulations in MSI CRC were EOMESHIGHCD8+ T memory-exhausted, CD8+ T central-memory, CD8+ T exhausted, CD8+ T partially activated and MAIT-like (Fig. 1d), aligning with the established tendency of MSI CRC to enrich memory/exhaustion signaling1,18.