IFNG+CD8+ T cells possessing viral TCRs also had relatively distinct features (Fig. 3g, h), i.e., while MSI CRC cells with viral TCRs enriched for largely metabolic pathways yet MSS CRC cells with viral TCRs enriched for either immunogenic pathways like IFN signaling, antigen presentation or IL4/IL13 immunosuppression. This evidence concerns the gene IL4 and colorectal carcinoma.