CD8A and neoplasm: Interestingly, a network topology-based analysis for network expansion (WEB-based Gene SeT AnaLysis Toolkit)41 showed that the genes constituting the tumor-reactive signaling modules on single cell CD8+ T cell level, also pre-dominantly connected to lymphocytes or T cell-relevant pathways in TCGA CRC dataset’s bulk tumor transcriptomes (Supplementary Fig. S6a).