Nevertheless, both MSI and MSS CRC CD8+ T cell subpopulations showed variable overlaps for the following states: effector/activated (IFNG, TNF, PRF1, CCL5 and/or GZMA/B/K), memory-exhausted (TOX, EOMES), or exhaustion (immune-inhibitory receptor (IR) genes: HAVCR2, ENTPD1, CTLA4, LAG3, TIGIT, and/or PDCD1) (Supplementary Table S2 and Fig. S2c, d). This evidence concerns the gene CTLA4 and colorectal carcinoma.