For several key regulators coding for exhaustion-relevant IRs/TFs, the gene expressions between MSI and MSS CRC IFNG+CD8+ T cells were not different, e.g., NFATC3, STAT2, PRDM1, STAT1, TIGIT, PDCD1, TBX21, TOX (Supplementary Fig. S3d). Here, TOX is linked to colorectal carcinoma.