Indeed these genes together enriched for various pathways relevant for tumor-reactive exhaustion or multi-factorial tumoral inflammation7,31,42,43 including nuclear factor of activated T cells (NFAT) signaling, IFNG signaling, various IL-based pathways including IL2/IL15, TGFβ signaling, and various T cell-relevant transcriptional pathways (Supplementary Fig. S3c). This evidence concerns the gene TGFB1 and neoplasm.