CD8A and colorectal carcinoma: Whereas in case of MSS CRC, IFNG+CD8+ T cells split into three mixed subpopulations: TCR-activationLOWbystander-activationLOW, TCR-activationHIGHbystander-activationLOW and TCR-activationLOWbystander-activationHIGH (Fig. 2i).