Across CD8+ T cells, in both MSI and MSS CRC, there were similar highly expressed genes, relevant for antigen-presentation or activation (B2M, HLA-A/B/C/E, CD74), effector activity (CCL5, NKG7, SRGN) or inflammation (JUN, IL32) (Fig. 1e, f). This evidence concerns the gene JUN and colorectal carcinoma.