CD8A and neoplasm: Hence, we investigated if the 22 MSI CRC and 38 MSS CRC patients (due to thresholding) can be broadly stratified on the tumor-reactive signaling modules (using hierarchical clustering of per patient means of the tumor-reactive modules), and how such stratification aligns with other annotations like CD8+ T cell subpopulations, TCR-to-bystander activation status, and IRs-coding genes’ expression.