In contrast, MSS CRC CD8+ T cells exposed a lot more contradictory inflammatory markers, i.e., immuno-regulation (PD-131), suppressor of T cell activity (CD3886), T cell activation (CD28, CD4487,88) and unconventional T cells (NKp4689) (Fig. 4f, h). The gene discussed is CD28; the disease is colorectal carcinoma.