TBX1 and pancreatic neoplasm: Recent studies have shown that PFD modulates CAFs to inhibit pancreatic tumor growth in situ and liver metastases from pancreatic tumors.[12] Therefore, reducing the generation of extracellular matrix through PFD and inhibiting CAFs in the tumor tissue may potentially enhance subsequent drug perfusion and oxygen supply, and increase the sensitivity of BETi.[13] Combining BETi and PFD in the treatment of pancreatic cancer may exert unique effects.