The MYC family ofprotooncogenes (MYC, MYCN, and MYCL) includes themost commonly amplified genes in cancer and is associated with greatertumor aggressiveness across tumor types.25,26 These genes encode basic helix–loop–helix (bHLH) transcriptionfactors involved in the regulation of cell growth, proliferation,and apoptosis. This evidence concerns the gene MYC and neoplasm.