Because around 70% of obese children develop liver fibrosis at the time of diagnosis for NAFLD,6 we examined whether the offspring in the HH arm of WT mice develop fibrosis, and whether the elimination of the ph-S193-C/EBPα-p300 pathway in C/EBPα-S193A mice inhibits development of fibrosis. This evidence concerns the gene EP300 and fibrosis.