,18 Moreover, we have recently found that human de-ph-Ser190-C/EBPα (human S190 is an analog of mouse S193 and de-phosphorylation on this residue mimics the S193A mutation) forms complexes with HDAC1, and that these C/EBPα-HDAC1complexes down-regulate hepatocyte specific genes in liver cancer.28 This evidence concerns the gene HDAC1 and liver cancer.