SMAD3 and neoplasm: By analyzing the transcriptome dynamics of TAM at single‐cell resolution, we identified Runx1, a transcription factor associated with hematopoiesis,[28] as a key driver for MMT under LLC‐tumor microenvironment.[22] Interestingly, although there have been indications of a connection between Smad3 and Runx1,[29, 30] their direct molecular mechanism remains unexplored.