By scRNA‐seq analysis with a public NSCLC dataset, we confirmed that Runx1 was highly expressed in the human MMTs (α‐SMA+CD68+, Figure 1B), where CAF signatures (α‐SMA, Fibroblast activation protein (FAP), Fibronectin 1 (FN1)) were markedly up‐regulated in the Runx1high MMTs (Figure 1C). This evidence concerns the gene ACTA1 and non-small cell lung carcinoma.