Interestingly, we detected a strong positive correlation between Runx1 and Smad3 in the lung adenocarcinoma TCGA cohort at transcriptome level (p = 5.4 × 10−14; Figure3A), which was further confirmed in our NSCLC cohort with multiplex IHC staining at protein level (p = 0.0008; Figure 3B; Figure S2, Supporting Information). Here, RUNX1 is linked to lung adenocarcinoma.