TGFB1 and non-small cell lung carcinoma: Interestingly, recent studies have revealed a potential link between Runx1 and CAF differentiation, where Runx1‐dependent stromal gene signature was identified in CAFs isolated from 4T1 tumors compared to normal fibroblasts in vivo,[33] and Runx1 silencing blocked TGF‐β1‐induced differentiation of human lung fibroblasts into myofibroblasts in vitro.[34] In line with this notion, we observed a dramatic increase in Runx1 expression in NSCLC and MMTs at the single‐cell resolution and found its positive correlation with CAF marker expression in TCGA cohort of lung adenocarcinoma.