Interestingly, recent studies have revealed a potential link between Runx1 and CAF differentiation, where Runx1‐dependent stromal gene signature was identified in CAFs isolated from 4T1 tumors compared to normal fibroblasts in vivo,[33] and Runx1 silencing blocked TGF‐β1‐induced differentiation of human lung fibroblasts into myofibroblasts in vitro.[34] In line with this notion, we observed a dramatic increase in Runx1 expression in NSCLC and MMTs at the single‐cell resolution and found its positive correlation with CAF marker expression in TCGA cohort of lung adenocarcinoma. Here, RUNX1 is linked to lung adenocarcinoma.