The 19 Talaromycosis marneffei patients in this study showed prominent clinical symptoms of respiratory system involvement, such as cough, expectoration, chest tightness, shortness of breath, and lung shadows, accompanied by systemic inflammatory responses that were manifested as fever, anaemia, weight loss, hypoalbuminemia, significantly increased levels of WBCs and neutrophils, elevated platelet counts, and varying degrees of increased anaemia and levels of the inflammatory indicators ESR, CRP, and PCT. This evidence concerns the gene ESR1 and anemia.