Also, in CF-T16AKO epithelia under inflammatory conditions, the FSK-induced alkalinization was significantly greater (P < 0.0001) compared to CF-T16AKO epithelia under normal conditions (7.6 ± 0.3 and 6.9 ± 0.4, n = 27 respectively, Fig. 2F). The gene discussed is CFTR; the disease is cystic fibrosis.