In the current studies using adult micewith 6 min of cardiac arrest followed by effective resuscitation,the unhealthy pyramidal neurons in the hippocampal CA1 region showlarge variabilities, ranging from mild to severe neuronal loss mimickingthe broad neurological scores seen in human cardiac arrest patients.Moreover, the degrees of severity of neuronal damage, measured byH&E staining of unhealthy neurons and a decrease in Map2+ density indicating dendritic (neurite) loss, are associated withthe activation of GFAP+ astrocytes and Iba1+ microglia in the hippocampal CA1 region. The gene discussed is MAP2; the disease is cardiac arrest.