Peripheral neuropathy is one the main type of neurological EIM in CD and the following factors can play a causal role in its development: chronic inflammatory activity of the underlying intestinal disease, macro/micronutrient absorption disorders, intercurrent viral infections or adverse effects of CD therapy (including metronidazole, sulfasalazine or anti-TNFα biological therapy) [4, 8]. The gene discussed is TNF; the disease is peripheral neuropathy.