The prevailing mechanism proposed to explain this relationship appears to be the pathological nature of overweight/obesity-driven adipose tissue that results in secretion of proinflammatory cytokines such as IL-6 and TNFa, which then stimulate an acute hepatic response, resulting in increased hsCRP levels (among other effects) [45]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.