Given that LATE-NC shares some similar morphologic features and a common protein inclusion (TDP-43) with other neurodegenerative diseases, including FTLD-TDP (types A–E) and ALS, there remains debate as to the nature of LATE-NC and its relationship to these other entities (5, 8, 40, 41). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.