TARDBP and age: Previously termed “hippocampal sclerosis of aging,” “hippocampal sclerosis dementia,” and “cerebral age-related TDP-43 and sclerosis” (2), LATE-NC is characterized by transactive response (TAR) DNA-binding protein of 43-kDa (TDP-43)-immunoreactive neuronal cytoplasmic inclusions (3), which originate in the amygdala (Stage 1) and progress to the hippocampus (Stage 2) and middle frontal gyrus of the neocortex (Stage 3) (1, 4).