ADO and neoplasm: Thus, after CL8-1 tumor melanoma cell xenotransplantation in mice, pharmacological inhibition or genetic deletion of the A2A receptor enhanced the inhibition of tumor growth, vascularization, and the destruction of metastases by incoming antitumor T lymphocytes [92], demonstrating that the ADO/A2A receptor pathway is essential for the modulation of immune host-tumor interactions.