Increased Ca2+ activity in microglial cells exposed to Aβ may be due to Aβ-evoked UTP/UDP release by stressed neurons acting on microglial metabotropic P2Y6 receptors [57] or Aβ-mediated mechanotransduction mediated via PIEZO1 Ca2+-permeable ion channels involved in amyloid clearance [29, 30]. The gene discussed is PIEZO1; the disease is amyloidosis.