Plasma exosomal CD54 expression levels were closely related to tumor size (p=0.0308), distant metastasis (p<0.0001), smoking history (p<0.0004), drinking history (p<0.0002), and clinical stage (p<0.0001), regardless of age (p=0.449) and gender (p=0.349). The gene discussed is ICAM1; the disease is neoplasm.