SIRT2 and lung carcinoma: We examined the potentialfor full-length SIRT2 to dimerize in human lung cancer cells (A549)using a split-GFP approach.28 We simultaneouslyexpressed two SIRT2 constructs, where one form contained a GFP fragmenton its N-terminus, and the other SIRT2 construct contained the complementaryGFP fragment on its C-terminus (Figure 4A).