Path/LP variants found in ACC are involved in negative regulation of cell cycle and cell-cycle arrest (ATM, ATRX, CDKN2A, CDKN2B, CTNNB1, MSH6, and TP53), chromatin remodeling and organization (ATM, ATRX, CDKN2A, CTNNB1, and KMT2A), DNA repair and response to DNA damage (ATM, ATRX, MLH1, MSH6, and TP53), and intrinsic apoptosis (ATM, MLH1, MSH6, and TP53). The gene discussed is TP53; the disease is adrenal cortex carcinoma.