CDK6 and colitis: Moreover, the microRNA bta-let-7a-5p, which is most prevalent in EVs of bovine colostrum, attenuated the symptoms of colitis via regulating the target gene Cdk6 and modulating the intestinal immunity of mice, suggesting that the possible immunomodulatory effects of bovine colostrum EVs and its miRNA were linked to the alteration in the gut microbial composition and immune-related gene regulation (Fig. 7).