To define the mechanism of LAIR-1–mediated leukemic growth arrest and cell death, we quantified the degree of cell death induced through LAIR-1 ligation by performing ex vivo culture of red blood cell–depleted (RBC-depleted) AML patient whole blood in the presence of NC525 or isotype control, followed by measurement of live and dead cell populations by flow cytometry (Supplemental Table 3 and Supplemental Figure 3A). The gene discussed is LAIR1; the disease is acute myeloid leukemia.