Of the paratope-positive tumor-infiltrating cells, 40A3Bz cells revealed functional activation as shown by the induction of IFN-γ+TNF+ cells (Pop2), whereas 40A3Bz dnTGFβRII CAR-Ts displayed functional activation and proliferation as shown by induction of IFN-γ+TNF+IL-2+ (Pop1) and TNF+IL-2+ cells (Pop0) as assessed by uniform manifold approximation and projection (UMAP) analysis (Figure 5E). The gene discussed is TNF; the disease is neoplasm.