ALOX5 and cancer: Considering that high expression of 5‐LOX resulted in LTB4 upregulation49 and persistent elevation of LTB4 has been reported in cancer,30 PIK3CAmut activating the 5‐LOX/LTB4 axis in LBC cells not only aggravated the suppressive TIME but also hampered the efficacy of immunotherapy by facilitating the migration and function of MDSCs.