Compared with the controls, alpelisib, LY255283 and anti‐PD‐1 mAb alone or combined treatment significantly inhibited the growth (Figure 7G,H) and the weight of PIK3CAmut xenografts (Figure 7I,J), especially the combination of alpelisib, LY255283 and anti‐PD‐1 mAb, which displayed the most significant suppression of tumour growth, suggesting that blocking the PI3K/5‐LOX/LTB4 axis by either PIK3CA inhibitor or LTB4 inhibitor considerably improved the efficacy of ICB therapy in PIK3CAmut tumours. This evidence concerns the gene PIK3CA and neoplasm.