To explore the mechanism involved in PIK3CAmut‐associated upregulation of ALOX5 in LBC cells, we screened the most significantly upregulated proteins in PIK3CAmut cancer cells using proteomics data from the TCGA database, and found increased phosphorylation levels of both Akt and STAT3 proteins in PIK3CAmut patients in the TCGA cohort (Figure 4A,B). The gene discussed is STAT3; the disease is cancer.