Smoker (odds ratio [OR] = 5.92, p = 0.023), EGFR+ (OR = 0.08, p = 0.022), and high CA125 (OR = 3.56, p = 0.047) were independent predictors of TMB‐high for NSCLC, and smoker (OR = 27.08, p = 0.018), EGFR+ (OR = 0.03, p = 0.033), KRAS+ (OR = 7.98, p = 0.083), high CEA (OR = 33.56, p = 0.029), and high CA125 (OR = 13.68, p = 0.030) were independent predictors of TMB‐high for ADC. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.