YTHDC2 and colorectal carcinoma: Elevated IGF2BP2 has been detected in CRC, and its function has been found to be the same as that of YTHDC2 in GC, i.e., it promotes the stability and translation of YAP by recognizing its mRNA, activating ErbB2 and leading to a malignant phenotype in CRC cells (Cui et al., 2021a).