The knockdown of METTL14 contributes to the progression of CRC via the recognition of YTHDF2, which modifies XIST, which is related to tumorigenesis in CRC by reducing its degradation (Patil et al., 2016; Yang et al., 2020c), similar to the function of METTL14 in GC. The gene discussed is METTL14; the disease is colorectal carcinoma.