Li et al. also reported that increased METTL3 expression in CRC is associated with metastasis; furthermore, METTL3 can reduce the degradation of the downstream factor SRY (sex determining region Y)-box 2 (SOX2), by methylating coding sequence regions by an IGF2BP2-dependent mechanism, in which K homology domains of IGF2BPs are responsible for tumorigenesis (Huang et al., 2018; Li et al., 2019). Here, METTL3 is linked to colorectal carcinoma.