ALKBH5 functions in esophageal cancer cells (ESCC), and its overexpression results in the inhibition of proliferation, migration, and invasion by arresting cells in the G1 phase (Xiao et al., 2021); however, demethylated mRNA of ALKBH5 and related signaling pathways in ESCC are unclear. Here, ALKBH5 is linked to esophageal squamous cell carcinoma.