In vitro and in vivo assays have shown that circLPAR1 in exosomes can sponge RNA-binding proteins (RBP) elF3h, reducing their binding to METTL3 in CRC cells, resulting in decreased translation of BRD4 mRNA and the suppression of CRC (Zheng et al., 2022) (Figure 3B). This evidence concerns the gene METTL3 and colorectal carcinoma.