YTHDF2 and colorectal carcinoma: Chen proposed a more complex mechanism of m6A regulation in CRC involving gut microbiota, in which Fusobacterium nucleatum facilitates metastasis by downregulating METTL3 via the inhibition of the HIPPO signaling pathway, activation of YAP signaling pathways, and elevation of the expression of the oncogene KIF26B due to reduced YTHDF2-dependent degradation (Chen et al., 2022a; You et al., 2022).