METTL3 and colorectal carcinoma: Additionally, m6A methylation of human Polycomb 3 (CBX8) increases chemoresistance in colon cancer by maintaining the stability of CBX8 mRNA (Zhang et al., 2019c).There is evidence suggesting that chemotherapeutic resistance in CRC relies on METTL3-mediated Sec62 expression (Liu et al., 2021).