The invasion and metastasis of CRC can also be modulated by the lncRNA RP11 methylation mediated by METTL3, and the formation of the RP11/hnRNP2B1/mRNA complex leads to the upregulation of the EMT-related factor Zeb1 (Wu et al., 2019). Here, METTL3 is linked to colorectal carcinoma.