METTL3 and esophageal squamous cell carcinoma: For example, METTL3 promotes the development of esophageal squamous cell carcinoma (ESCC) through the stabilization of NOTCH1 and EGR1 mRNA, followed by activation of Notch and EGR1/Snail signaling pathways (Li et al., 2021a; Han et al., 2021).