TAMs in these diverse cancer types express programmed death-ligand 1 (PD-L1) (Sumitomo et al., 2019; Shinchi et al., 2022; Xia et al., 2022; Elomaa et al., 2023), which interacts with the PD-1 receptor on T cells (Pereira et al., 2023; Puig-Saus et al., 2023) and NK cells (Zhou et al., 2023a; van der Sluis et al., 2023), leading to their exhaustion and promoting tumour immune evasion. Here, CD274 is linked to cancer.