Importantly, TAM-derived TGF-β induces epithelial-to-mesenchymal transition (EMT) of cancer cells (Cai et al., 2019; Tiwari et al., 2021), allowing them to migrate into surrounding tissue and vasculature (Dongre and Weinberg, 2019; Wang et al., 2021b). Here, TGFB1 is linked to cancer.