VDAC2 and neoplasm: Li et al. also showed that the inherent tripartite motif 21 of tumor cells promotes VDAC2 degradation through K48-linked ubiquitination, which inhibits the pore-forming capacity of VDAC2 oligomers and reduces mtDNA leakage, which in turn inhibits the type I interferon response following exposure to IR (Li et al., 2023).