STING1 and neoplasm: STING, through activation of the downstream NF-κB pathway, also mediates the secretion of pro-inflammatory cytokines, chemokines, proteases, and growth factors, collectively referred to as SASPs (senescence-associated secretory phenotypes), which attenuate tumor growth by promoting cell cycle arrest in tumor cells (Dou et al., 2017; Yang et al., 2017).