Therefore, in this review, we summarize the main mechanisms of mtDNA escaping from mitochondria and the recent advances in the impact on tumor cells after the occurrence of horizontal metastasis, with a focus on the role of the subsequent non-innate immunoregulatory pathways of the cGAS-STING pathway in tumor progression and the potential factors that influence STING bi-directionality. This evidence concerns the gene CGAS and neoplasm.