Due to the inherent genomic instability of cancer cells, they can display constitutive activation of intrinsic immunity and cGAS-STING pathway-mediated IFN signaling, with the production of IFN-a and IFN-b that bind to IFN receptors on themselves, neighboring cells or immune cells, mobilizing immune cells such as dendritic cells (DCs) and TME infiltration of CD8+T cells to eliminate the tumor (Diamond et al., 2011; Fuertes et al., 2011; Reislander et al., 2020). Here, CD8A is linked to neoplasm.