IFNA1 and Flavivirus Infections: The capacity of type I IFN to restrict flavivirus infection has also been confirmed in therapeutic disease models, since pretreatment with IFN-α or inducers of IFN-α has been shown to attenuate viral dissemination and to improve clinical outcome in mice or hamsters infected by several viruses (Brooks and Phillpotts, 1999; Leyssen et al., 2003; Morrey et al., 2004; Julander et al., 2007; Chan et al., 2016).