APP and Alzheimer disease: In a previous work, STX1A has been associated to Aβ oligomers accumulation, which directly inhibit SNARE-mediated exocytosis in APP/PS1 TG mice, and considered the main pathogenic culprits for AD-related deficits in learning, memory and synaptic plasticity (Bornemann and Staufenbiel, 2000; William et al., 2012; Yang et al., 2015).