MAPT and Alzheimer disease: In this framework, some of the major traits of cognitive decline might be related to the pathological extracellular Aβ deposition and intracellular tau aggregation, together with an impaired intracellular degradative pathway (autophagy), which are regarded as hallmarks for the early onset of Alzheimer’s disease in humans and animals (Reddy et al., 2018; Rao et al., 2022).