TNF and neoplasm: Inflammatory cytokines, such as interleukin-6, tumor necrosis factor alpha, and so forth, are produced by the tumor micro-environment cells, which in NHL represents mostly about 10% of tumor mass, while in HL the cytokines are produced not only by large amount of tumor microenvironment cells but also by the Hodgkin and Reed–Sternberg cells (53, 54).