GREM1 and colorectal carcinoma: There are few other genes reported in the literature such as RNF43 (associated with serrated polyposis CRC; RNF43-associated serrated polyposis syndrome) and GREM1 (associated with mixed polyposis CRC; GREM1-associated mixed polyposis) in few affected individuals, but their prevalence is not yet well known and are less common in CRC multigene panel designs (22, 23).