In addition to the four MMR genes (MLH1, MSH2, MSH6, and PMS2), the gene EPCAM is included in an NGS multigene panel because it has a well-established association with the most common hereditary CRC syndrome, LS, due to deletions in this gene leading to MSH2 hypermethylation (26–28). The gene discussed is MSH2; the disease is Leigh syndrome.