There are few other genes reported in the literature such as RNF43 (associated with serrated polyposis CRC; RNF43-associated serrated polyposis syndrome) and GREM1 (associated with mixed polyposis CRC; GREM1-associated mixed polyposis) in few affected individuals, but their prevalence is not yet well known and are less common in CRC multigene panel designs (22, 23). Here, RNF43 is linked to colorectal carcinoma.