FOXO3 and medical procedure: In addition, TP53INP1 and two members of the FOXO family, FOXO1 and FOXO3a, which are genes directly targeted by miR-96, were identified, and their discovery may facilitate the elucidation of the regulatory mechanism underlying miR-96 effects on colorectal carcinogenesis (57).Transfection of miR-223 inhibitors markedly upregulated FOXO3a expression, increased Bim levels, attenuated cell proliferation, and potentiated apoptosis in SW620 colorectal cancer cells (58).