FOXO3 and cancer: AKT, a classical signal transduction factor, regulates cell growth through its action in phosphorylating other proteins in its pathway, and a study showed that when overexpressed, miR-182-5p reduced the level of FOXO3a to promote the proliferation of cancer cells via activation of the AKT signalling pathway and the downstream targets Bcl-2 and Bcl-xl (27).