When miR-485-5p and miR-498 were combined with long-chain non-coding RNAs, respectively, FOXO3a acted as a cancer-promoting agent, it is possible that the incorporation of long-stranded non-coding RNAs leads to the alteration of the SNPS site of FOXO3a, which is proved to trigger cancer or increase the risk of cancer (70–72), and the specific reasons need to be further investigated in depth. This evidence concerns the gene FOXO3 and cancer.