FOXO3 and neoplasm: Moreover, FOXO3a has been proposed to combine with and induce the transcription of the long noncoding RNA LOC554202 promoter region, and this finding was confirmed by experiments showing that FOXO3a contributes to hepatocellular carcinoma progression by upregulating LOC554202 expression; both FOXO3a and LOC554202 thus promoted tumour cell growth.