FOXO3 and neoplasm: Dual luciferase reporter assays can verify a targeted relationship between microRNAs and FOXO3a, and the significance of multiple microRNAs such as miR-372, miR-96-5p, miR-629 and other microRNAs targeting and mediating FOXO3a activity in gastric cancer cell proliferation and development or mediating cisplatin resistance has been proven (47–49).Moreover, microRNAs foster tumour progression and play an active role in the acquisition of a cisplatin-resistant phenotype.