There are twelve microRNAs antagonizing FOXO3a to promote individual tumour cell growth (Figure 3B), in addition to that, five microRNAs, miR-155, miR-21, miR-182-5p, miR-96, and miR-223, can antagonize FOXO3a to promote a variety of cancer progression (Table 1), at the same time, we discovered that the effects of a single microRNA antagonizing FOXO3a on various cancers also yielded inconsistent results. Here, FOXO3 is linked to cancer.