In an alternative explanation, the inhibitory action of miR-498 in hepatocellular carcinoma was possibly too vigorous, and thus attenuates the tumour-suppressing effect of FOXO3a, in addition, possibly due to the presence of long noncoding RNAs that interfered with FOXO3a expression through some unknown mechanism. The gene discussed is FOXO3; the disease is hepatocellular carcinoma.