In a survey of the malignant progression of hepatopulmonary metastasis in gastric cancer, miR-582 was reported to inhibit FOXO3a expression through complementary targets, thereby contributing to the PI3K/AKT/Snail signalling pathway to accelerate hepatopulmonary metastasis, and similar results were obtained with mice (45). The gene discussed is FOXO3; the disease is gastric cancer.