Wnt signalling plays a role in maintaining cell mitosis and stem cell renewal, indicating that the upregulation of FOXO3a expression played a significant role in inhibiting the progression of hepatocellular carcinoma by suppressing the kinase expression level, and research has shown that FOXO3a is an important interfering factor in the malignant behaviour of hepatocellular carcinoma. This evidence concerns the gene FOXO3 and hepatocellular carcinoma.