FOXO3 and colorectal neoplasm: Evidence suggests that when GAS5 is overexpressed in colorectal tumour cells, the FOXO3a level is synergistically increased and plays an indispensable role in repressing the proliferation of colorectal tumour cells, and the addition of miR-182-5p blocks the GAS5-induced upregulation of FOXO3a protein expression (60).