FOXO3 and hepatocellular carcinoma: Various studies have been conducted to investigate the potential functions of FOXO3a in hepatocarcinogenesis, and miR-155 has been found to inhibit the apoptosis of hepatocellular carcinoma cells by inhibiting FOXO3a action, thereby reducing the activity of the downstream proapoptosis protein Bim and weakening the activity of caspase-9 and caspase-3 (31).