When the analysis was performed by combining clinical factors (age, CEA level, histology, lymphovascular invasion, perineural invasion, stage T, and stage N) and tumor microbiome data (selecting only the genera with a relative abundance greater than or equal to 1%), we found that CEA level, T stage, and perineural invasion (among clinical factors), as well as the tumor tissue microbiome (including Gemella, Parabacteroides, Parasutterella, and Prevotella) were significant. This evidence concerns the gene CEACAM5 and neoplasm.