TNF and obesity due to melanocortin 4 receptor deficiency: Dyslipidemia and obesity in people with psoriasis can lower lifespans and increase the chances of systemic and metabolic conditions; hence, it is imperative to routinely investigate such complications in psoriasis patients. Recent research has shown that obesity has a mildly pro-inflammatory state with elevated amounts of tumor necrosis factor and IL-6, which may cause or aggravate lesions related to psoriasis [43]. Severe abnormalities in lipids are present in individuals with psoriasis.