CASP8 and Lymphadenopathy: Recent studies on a cohort of patients with a newly-described cluster of autoimmune symptoms (CRIA), characterized by early onset fevers and lymphadenopathy, were found to have common underlying gain-of-function mutations which rendered Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) protein resistant to caspase 8 (Casp8) cleavage.