RIPK1 and Autoimmunity: Given the CRIA syndromes which implicate RIP kinases in autoimmunity, the data described above, and as a corollary to our recent publication which established a role for RIPK1 in innate B cell development (11), we hypothesize that RIPK1 functions as a rheostat to relay TcR signal strength which influences innate T cell development and function.