A high L/S ratio remained a significant predictor of poor OS and DFS in multivariate analysis adjusting the model for age, PR expression, ER+/HER2-, HER2+ and TNBC subtype, treatment adequacy, history of malignancy and tumor size with cutoff at 10mm OS (HR=2.357, 95%CI 1.458-3.812, p<0.001), DFS (HR=1.810, 95%CI 1.187-2.760, P=0.006). This evidence concerns the gene PGR and neoplasm.