Mechanistically, they demonstrated that histone lactylation accelerates ocular melanoma progression by promoting the expression of the m6A reading protein YTHDF2, which recognizes m6A-modified PER1 and TP53 mRNAs and promotes their degradation (59), this study bridges the gap between histone modifications and RNA modifications, providing a new understanding of epigenetic regulation in tumorigenesis development. The gene discussed is PER1; the disease is ocular melanoma.