METTL3 and colonic neoplasm: claimed that the increased expression of m6A methyltransferase-like 3 (METTL3) in TIMs was associated with poor prognosis in colon cancer patients, and mechanistically, they found that the accumulated lactate in TME can promote the upregulation of METTL3 in TIMs via inducing lactylation of H3K18.