has reported the effects of lactate on non-small cell lung cancer (NSCLC) metabolism and confirmed that lactate dehydrogenase (LDH) upregulation was associated with poor prognosis in NSCLC, and that lactate regulated the expression of the glycolytic enzyme HK-1 and the TCA cycle enzyme IDH3G. The gene discussed is HK1; the disease is non-small cell lung carcinoma.