has reported the effects of lactate on non-small cell lung cancer (NSCLC) metabolism and confirmed that lactate dehydrogenase (LDH) upregulation was associated with poor prognosis in NSCLC, and that lactate regulated the expression of the glycolytic enzyme HK-1 and the TCA cycle enzyme IDH3G. Here, IDH3G is linked to non-small cell lung carcinoma.