While all of the individual genes comprising the type I and II IFN, PB, and activation/exhaustion T cell modules were significantly different between cSLE and HC groups (Figure 1, Supplementary Figure 2C), only PDCD1 and LAG3 were significantly different between cSLE patients with and without LN (Supplementary Figure 2C). This evidence concerns the gene PDCD1 and lobular neoplasia.