We applied CellCnn analyses to B cells from LN vs. No LN patients based on intracellular cytokine production and identified an LN-associated B cell population (p = 0.00778, median LN = 3.15% vs. No LN = 1.06%; Figures 7A, B) with elevated IFN-γ, MCP-1, IL-12p40, PTEN, IL-23p19, IFN-α, and IL-6 (Figure 7C). Here, IFNG is linked to lobular neoplasia.