Because the ASC in SLE likely derive from precursors with autoreactive specificity that escape anergy, we evaluated the anergic B cell compartment (Bnd, CD27-IgM-IgD+) and found a trend toward reduced frequency in cSLE patients (p = 0.087, median SLE = 5.50% vs. HC = 6.40%; Figure 5A). This evidence concerns the gene CD27 and systemic lupus erythematosus.